Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Located in centrosome; cytosol; and nucleoplasm. Implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IQSEC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IQSEC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IQSEC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:12,993,065–12,995,303 | 288.2 kb | Distal (>10kb) Multiome | 920 | |
| chr3:13,092,039–13,092,618 | 190.9 kb | Distal (>10kb) Multiome | 307 | |
| chr3:13,157,648–13,158,706 | 125.1 kb | Distal (>10kb) Multiome | 19 | |
| chr3:13,281,536–13,283,868 | 295 bp | At TSS Multiome | 567 | |
| chr3:13,301,084–13,301,878 | 18.2 kb | Distal (>10kb) Multiome | 345 | |
| chr3:13,419,449–13,420,954 | 137.0 kb | Distal (>10kb) Multiome | 719 | |
| chr3:13,451,423–13,452,307 | 168.6 kb | Distal (>10kb) Multiome | 750 | |
| chr3:13,479,315–13,481,211 | 196.9 kb | Distal (>10kb) Multiome | 821 | |
| chr3:13,546,672–13,547,232 | 263.7 kb | Distal (>10kb) Multiome | 324 | |
| chr3:13,548,548–13,549,592 | 265.8 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the IQSEC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.