This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for ERV3-1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERV3-1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERV3-1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:64,793,972–64,795,082 | 212.3 kb | Distal (>10kb) Multiome | 726 | |
| chr7:64,887,970–64,889,709 | 118.4 kb | Distal (>10kb) Multiome | 308 | |
| chr7:64,902,559–64,903,772 | 103.5 kb | Distal (>10kb) Multiome | 497 | |
| chr7:64,998,057–64,998,217 | 8.5 kb | Proximal (<10kb) | 133 | |
| chr7:65,006,175–65,006,968 | 17 bp | At TSS Multiome | 666 | |
| chr7:65,037,736–65,039,147 | 31.5 kb | Distal (>10kb) Multiome | 335 | |
| chr7:65,080,759–65,081,624 | 74.6 kb | Distal (>10kb) Multiome | 273 | |
| chr7:65,233,376–65,233,924 | 227.0 kb | Distal (>10kb) Multiome | 61 | |
| chr7:65,239,449–65,240,350 | 233.2 kb | Distal (>10kb) Multiome | 420 | |
| chr7:65,251,663–65,252,869 | 245.6 kb | Distal (>10kb) Multiome | 690 | |
| chr7:65,268,929–65,270,162 | 262.6 kb | Distal (>10kb) Multiome | 581 |
Genomic view of the ERV3-1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.