The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for IFT81. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT81 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT81, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:109,833,102–109,833,778 | 290.9 kb | Distal (>10kb) Multiome | 217 | |
| chr12:109,845,155–109,845,762 | 278.9 kb | Distal (>10kb) Multiome | 618 | |
| chr12:109,880,019–109,881,173 | 243.8 kb | Distal (>10kb) Multiome | 576 | |
| chr12:109,900,106–109,900,747 | 224.0 kb | Distal (>10kb) Multiome | 818 | |
| chr12:109,995,726–109,996,660 | 128.1 kb | Distal (>10kb) Multiome | 811 | |
| chr12:109,998,999–109,999,838 | 125.1 kb | Distal (>10kb) Multiome | 883 | |
| chr12:110,048,083–110,048,797 | 75.8 kb | Distal (>10kb) Multiome | 921 | |
| chr12:110,107,883–110,108,523 | 16.2 kb | Distal (>10kb) Multiome | 171 | |
| chr12:110,123,690–110,124,996 | 19 bp | At TSS Multiome | 704 | |
| chr12:110,223,831–110,224,526 | 99.7 kb | Distal (>10kb) Multiome | 199 | |
| chr12:110,280,425–110,282,158 | 156.8 kb | Distal (>10kb) Multiome | 888 | |
| chr12:110,403,190–110,403,822 | 279.4 kb | Distal (>10kb) Multiome | 779 |
Genomic view of the IFT81 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.