This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for NECTIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NECTIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NECTIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:119,481,243–119,481,846 | 247.6 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr11:119,584,125–119,585,601 | 144.8 kb | Distal (>10kb) Multiome | 491 | |
| chr11:119,616,862–119,617,652 | 112.1 kb | Distal (>10kb) Multiome | 70 | |
| chr11:119,727,349–119,728,053 | 1.5 kb | Proximal (<10kb) Multiome | 316 | |
| chr11:119,728,289–119,729,816 | 152 bp | At TSS Multiome | 719 | |
| chr11:119,729,929–119,730,206 | 729 bp | At TSS | 159 | |
| chr11:119,742,242–119,742,859 | 13.5 kb | Distal (>10kb) Multiome | 148 | |
| chr11:119,975,481–119,976,107 | 246.5 kb | Distal (>10kb) Multiome | 63 | |
| chr11:120,013,169–120,013,755 | 284.3 kb | Distal (>10kb) Multiome | 219 | |
| chr11:120,168,771–120,169,627 | 440.0 kb | Distal (>10kb) Multiome HiCAR | 478 |
Genomic view of the NECTIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.