The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GOLPH3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLPH3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLPH3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,487,154–150,487,710 | 209.8 kb | Distal (>10kb) Multiome | 929 | |
| chr1:150,515,085–150,516,227 | 181.5 kb | Distal (>10kb) Multiome | 781 | |
| chr1:150,548,849–150,549,823 | 147.9 kb | Distal (>10kb) Multiome | 620 | |
| chr1:150,560,828–150,562,623 | 135.8 kb | Distal (>10kb) Multiome | 897 | |
| chr1:150,578,554–150,580,300 | 117.6 kb | Distal (>10kb) Multiome | 990 | |
| chr1:150,629,012–150,630,122 | 67.7 kb | Distal (>10kb) Multiome | 875 | |
| chr1:150,634,804–150,635,486 | 61.9 kb | Distal (>10kb) Multiome | 113 | |
| chr1:150,641,008–150,641,820 | 55.6 kb | Distal (>10kb) Multiome | 66 | |
| chr1:150,696,689–150,696,843 | 310 bp | At TSS | 74 | |
| chr1:150,696,984–150,697,716 | 146 bp | At TSS Multiome | 619 | |
| chr1:150,875,863–150,877,222 | 179.5 kb | Distal (>10kb) Multiome | 912 | |
| chr1:150,925,543–150,926,754 | 229.2 kb | Distal (>10kb) Multiome | 813 | |
| chr1:150,973,876–150,975,458 | 277.7 kb | Distal (>10kb) Multiome | 590 | |
| chr1:150,979,331–150,979,990 | 282.4 kb | Distal (>10kb) Multiome | 562 | |
| chr1:150,981,212–150,981,672 | 284.2 kb | Distal (>10kb) Multiome | 379 |
Genomic view of the GOLPH3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.