Enables protein phosphatase binding activity and pseudophosphatase activity. Involved in negative regulation of stress granule assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of neuron projection development. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STYXL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STYXL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STYXL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:75,778,655–75,779,512 | 268.8 kb | Distal (>10kb) Multiome | 54 | |
| chr7:75,780,667–75,781,151 | 267.2 kb | Distal (>10kb) Multiome | 106 | |
| chr7:75,788,149–75,788,821 | 259.6 kb | Distal (>10kb) Multiome | 95 | |
| chr7:75,878,577–75,879,573 | 169.0 kb | Distal (>10kb) Multiome | 883 | |
| chr7:75,914,282–75,915,911 | 132.9 kb | Distal (>10kb) Multiome | 1021 | |
| chr7:75,993,473–75,995,401 | 53.3 kb | Distal (>10kb) Multiome | 873 | |
| chr7:76,047,582–76,048,952 | 59 bp | At TSS Multiome | 920 | |
| chr7:76,049,172–76,049,650 | 1.2 kb | Proximal (<10kb) | 136 | |
| chr7:76,050,376–76,050,863 | 2.4 kb | Proximal (<10kb) | 58 | |
| chr7:76,073,173–76,073,663 | 25.5 kb | Distal (>10kb) Multiome | 100 | |
| chr7:76,163,449–76,164,544 | 116.0 kb | Distal (>10kb) Multiome | 132 | |
| chr7:76,166,338–76,167,166 | 118.7 kb | Distal (>10kb) Multiome | 644 | |
| chr7:76,177,965–76,178,641 | 130.3 kb | Distal (>10kb) Multiome | 670 | |
| chr7:76,201,356–76,202,307 | 153.8 kb | Distal (>10kb) Multiome | 937 | |
| chr7:76,234,695–76,235,681 | 187.3 kb | Distal (>10kb) Multiome | 329 | |
| chr7:76,259,707–76,261,052 | 212.4 kb | Distal (>10kb) Multiome | 332 | |
| chr7:76,267,044–76,267,853 | 219.4 kb | Distal (>10kb) Multiome | 211 | |
| chr7:76,282,299–76,283,220 | 234.7 kb | Distal (>10kb) Multiome | 237 | |
| chr7:76,291,428–76,292,275 | 243.9 kb | Distal (>10kb) Multiome | 767 | |
| chr7:76,302,207–76,304,173 | 254.5 kb | Distal (>10kb) Multiome | 943 | |
| chr7:76,314,028–76,314,686 | 266.4 kb | Distal (>10kb) Multiome | 715 | |
| chr7:76,317,523–76,319,173 | 270.2 kb | Distal (>10kb) Multiome | 840 |
Genomic view of the STYXL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.