N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for NAA15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAA15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAA15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,014,635–139,016,468 | 285.8 kb | Distal (>10kb) Multiome | 975 | |
| chr4:139,020,400–139,021,056 | 280.9 kb | Distal (>10kb) Multiome | 167 | |
| chr4:139,082,831–139,084,775 | 218.5 kb | Distal (>10kb) Multiome | 1056 | |
| chr4:139,159,062–139,160,313 | 141.8 kb | Distal (>10kb) Multiome | 133 | |
| chr4:139,176,009–139,179,224 | 123.5 kb | Distal (>10kb) Multiome | 1018 | |
| chr4:139,279,361–139,280,628 | 21.3 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 5.7 kb | Proximal (<10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 153 bp | At TSS Multiome | 912 | |
| chr4:139,453,063–139,454,584 | 152.3 kb | Distal (>10kb) Multiome | 989 | |
| chr4:139,555,161–139,557,952 | 253.9 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the NAA15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.