The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DHX15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DHX15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DHX15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:24,412,946–24,413,938 | 171.1 kb | Distal (>10kb) Multiome | 162 | |
| chr4:24,469,795–24,472,485 | 114.2 kb | Distal (>10kb) Multiome | 494 | |
| chr4:24,472,584–24,473,681 | 111.4 kb | Distal (>10kb) Multiome | 565 | |
| chr4:24,583,502–24,585,060 | 56 bp | At TSS Multiome | 872 | |
| chr4:24,661,948–24,662,562 | 77.8 kb | Distal (>10kb) Multiome HiCAR | 55 | |
| chr4:24,795,107–24,795,850 | 211.0 kb | Distal (>10kb) Multiome | 178 | |
| chr4:24,799,487–24,800,855 | 215.5 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the DHX15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.