This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OPTN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OPTN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OPTN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:13,000,971–13,001,949 | 98.8 kb | Distal (>10kb) Multiome | 227 | |
| chr10:13,099,052–13,100,750 | 936 bp | At TSS Multiome | 675 | |
| chr10:13,120,751–13,121,780 | 21.1 kb | Distal (>10kb) Multiome | 155 | |
| chr10:13,161,059–13,162,040 | 61.3 kb | Distal (>10kb) Multiome | 746 | |
| chr10:13,299,293–13,300,384 | 199.8 kb | Distal (>10kb) Multiome | 850 | |
| chr10:13,302,089–13,302,853 | 202.3 kb | Distal (>10kb) Multiome | 807 | |
| chr10:13,347,195–13,348,918 | 248.0 kb | Distal (>10kb) Multiome | 753 | |
| chr10:13,349,410–13,350,393 | 249.8 kb | Distal (>10kb) Multiome | 432 | |
| chr10:13,351,365–13,351,877 | 251.4 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the OPTN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.