This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for DLG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:82,899,722–82,902,187 | 2726.7 kb | Distal (>10kb) Multiome HiCAR | 1001 | |
| chr11:83,241,143–83,241,871 | 2386.8 kb | Distal (>10kb) Multiome HiCAR | 285 | |
| chr11:83,285,491–83,286,808 | 2342.1 kb | Distal (>10kb) Multiome HiCAR | 1057 | |
| chr11:83,318,271–83,319,586 | 2309.4 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr11:83,443,851–83,444,454 | 2184.3 kb | Distal (>10kb) Multiome | 56 | |
| chr11:83,720,787–83,720,979 | 4.0 kb | Proximal (<10kb) | 13 | |
| chr11:83,722,447–83,722,643 | 2.3 kb | Proximal (<10kb) | 34 | |
| chr11:83,724,266–83,725,551 | 1903.3 kb | Distal (>10kb) Multiome | 319 | |
| chr11:83,725,818–83,725,972 | 862 bp | At TSS | 46 | |
| chr11:83,836,349–83,837,522 | 1791.6 kb | Distal (>10kb) Multiome | 244 | |
| chr11:84,719,746–84,721,467 | 907.5 kb | Distal (>10kb) Multiome HiCAR | 359 | |
| chr11:85,539,822–85,540,935 | 88.2 kb | Distal (>10kb) Multiome | 130 | |
| chr11:85,627,372–85,629,061 | 120 bp | At TSS Multiome | 826 | |
| chr11:85,647,447–85,648,443 | 19.6 kb | Distal (>10kb) Multiome | 808 | |
| chr11:85,663,762–85,665,466 | 36.7 kb | Distal (>10kb) Multiome | 999 | |
| chr11:85,809,696–85,811,885 | 182.9 kb | Distal (>10kb) Multiome | 535 | |
| chr11:85,854,605–85,855,812 | 226.7 kb | Distal (>10kb) Multiome | 948 | |
| chr11:86,244,135–86,246,099 | 616.6 kb | Distal (>10kb) Multiome HiCAR | 959 |
Genomic view of the DLG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.