This 26-gene module includes TGFBR1, ITGA5, KDM1A, NOTCH2, and ITGA6, with enrichment for cell surface and receptor complex components. Knockdown of ARID1A, KLF6, and SMAD4 activates this module, suggesting these factors normally repress cell surface receptor expression. Knockdown of SMAD5, SOX4, and SOX11 represses this module, indicating they support its expression during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.