The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for GOLM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:85,804,917–85,805,981 | 294.9 kb | Distal (>10kb) Multiome | 304 | |
| chr9:85,940,728–85,942,035 | 159.1 kb | Distal (>10kb) Multiome | 889 | |
| chr9:86,098,791–86,100,295 | 659 bp | At TSS Multiome | 436 | |
| chr9:86,118,248–86,119,118 | 18.4 kb | Distal (>10kb) Multiome | 10 | |
| chr9:86,126,993–86,127,913 | 27.4 kb | Distal (>10kb) Multiome | 439 | |
| chr9:86,186,986–86,187,492 | 87.1 kb | Distal (>10kb) Multiome | 90 | |
| chr9:86,281,630–86,283,173 | 182.4 kb | Distal (>10kb) Multiome | 959 | |
| chr9:86,353,702–86,354,978 | 254.3 kb | Distal (>10kb) Multiome | 1008 |
Genomic view of the GOLM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.