The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for ITGA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:172,131,690–172,132,350 | 295.6 kb | Distal (>10kb) Multiome | 102 | |
| chr2:172,172,453–172,173,020 | 254.9 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr2:172,234,493–172,235,728 | 192.4 kb | Distal (>10kb) Multiome HiCAR | 346 | |
| chr2:172,380,587–172,381,629 | 46.5 kb | Distal (>10kb) Multiome | 280 | |
| chr2:172,427,119–172,428,808 | 10 bp | At TSS Multiome | 799 | |
| chr2:172,429,611–172,430,353 | 2.4 kb | Proximal (<10kb) Multiome | 101 | |
| chr2:172,434,900–172,435,930 | 7.9 kb | Proximal (<10kb) Multiome | 213 | |
| chr2:172,436,080–172,436,562 | 8.5 kb | Proximal (<10kb) | 32 | |
| chr2:172,554,417–172,555,143 | 127.1 kb | Distal (>10kb) Multiome | 179 | |
| chr2:172,555,296–172,556,851 | 128.4 kb | Distal (>10kb) Multiome | 1053 | |
| chr2:172,674,529–172,675,178 | 247.2 kb | Distal (>10kb) Multiome | 202 |
Genomic view of the ITGA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.