This module contains 10 genes including SP3, EMSY, KIF2A, CHD1, and PPP3R1, with enrichment in chromatin remodeling, protein phosphatase activity, and microtubule dynamics. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN represses it. The module's regulatory pattern suggests coordination between chromatin state and phosphatase-dependent signaling during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.