Enables phosphatase binding activity and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP3R1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP3R1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP3R1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:68,062,503–68,063,411 | 188.1 kb | Distal (>10kb) Multiome | 755 | |
| chr2:68,120,653–68,121,790 | 129.9 kb | Distal (>10kb) Multiome | 486 | |
| chr2:68,156,957–68,158,339 | 93.4 kb | Distal (>10kb) Multiome | 970 | |
| chr2:68,250,908–68,253,446 | 1.6 kb | Proximal (<10kb) Multiome | 1015 | |
| chr2:68,318,412–68,319,996 | 68.5 kb | Distal (>10kb) Multiome | 484 | |
| chr2:68,466,807–68,468,080 | 216.3 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the PPP3R1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.