This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for UHRF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UHRF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UHRF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:6,364,728–6,365,487 | 48.1 kb | Distal (>10kb) Multiome | 58 | |
| chr9:6,411,893–6,414,477 | 97 bp | At TSS Multiome | 913 | |
| chr9:6,590,688–6,591,679 | 177.9 kb | Distal (>10kb) Multiome | 403 | |
| chr9:6,592,227–6,592,641 | 179.3 kb | Distal (>10kb) Multiome | 82 | |
| chr9:6,645,085–6,646,200 | 232.6 kb | Distal (>10kb) Multiome | 656 | |
| chr9:6,680,771–6,682,229 | 268.3 kb | Distal (>10kb) Multiome | 1070 | |
| chr9:6,692,445–6,693,412 | 279.7 kb | Distal (>10kb) Multiome | 196 | |
| chr9:6,703,765–6,704,853 | 291.1 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the UHRF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.