The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
Transcription factors with Perturb-seq knockdown data for BAZ1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAZ1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAZ1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,629,461–34,630,514 | 244.8 kb | Distal (>10kb) Multiome | 907 | |
| chr14:34,693,166–34,693,989 | 181.6 kb | Distal (>10kb) Multiome | 463 | |
| chr14:34,713,982–34,715,044 | 160.3 kb | Distal (>10kb) Multiome | 919 | |
| chr14:34,873,262–34,875,515 | 267 bp | At TSS Multiome | 1146 | |
| chr14:34,981,885–34,983,443 | 107.8 kb | Distal (>10kb) Multiome | 1124 | |
| chr14:35,045,870–35,047,118 | 171.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr14:35,121,659–35,123,040 | 247.1 kb | Distal (>10kb) Multiome | 1148 |
Genomic view of the BAZ1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.