This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for MARCHF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARCHF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARCHF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:10,101,981–10,102,627 | 251.4 kb | Distal (>10kb) Multiome | 152 | |
| chr5:10,102,752–10,103,804 | 250.3 kb | Distal (>10kb) Multiome | 152 | |
| chr5:10,156,936–10,157,799 | 196.3 kb | Distal (>10kb) Multiome | 159 | |
| chr5:10,249,033–10,250,873 | 103.6 kb | Distal (>10kb) Multiome | 961 | |
| chr5:10,307,259–10,308,125 | 45.9 kb | Distal (>10kb) Multiome | 733 | |
| chr5:10,332,886–10,333,985 | 20.1 kb | Distal (>10kb) Multiome | 288 | |
| chr5:10,352,751–10,354,487 | 3 bp | At TSS Multiome | 1042 | |
| chr5:10,357,945–10,358,331 | 4.2 kb | Proximal (<10kb) | 250 | |
| chr5:10,441,055–10,442,455 | 88.2 kb | Distal (>10kb) Multiome | 721 | |
| chr5:10,484,832–10,486,353 | 131.7 kb | Distal (>10kb) Multiome | 499 | |
| chr5:10,514,072–10,514,528 | 160.5 kb | Distal (>10kb) Multiome | 182 | |
| chr5:10,533,291–10,533,909 | 179.7 kb | Distal (>10kb) Multiome | 83 | |
| chr5:10,562,689–10,565,568 | 210.5 kb | Distal (>10kb) Multiome | 622 | |
| chr5:10,627,273–10,628,369 | 274.2 kb | Distal (>10kb) Multiome | 678 | |
| chr5:10,637,215–10,638,114 | 283.9 kb | Distal (>10kb) Multiome | 155 |
Genomic view of the MARCHF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.