This module contains 10 genes including PRKCA, CDKAL1, LTBP1, DGKH, and PDE8A, with enrichment in protein kinase activity and lipid signaling pathways. Knockdown of SMARCC1, SMAD3, and ARID1A activates this module. Knockdown of DR1, HES1, and SOX17 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.