Predicted to enable nucleic acid binding activity and zinc ion binding activity. Acts upstream of or within retina development in camera-type eye. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SCAPER. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SCAPER upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SCAPER, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:76,345,613–76,346,889 | 559.0 kb | Distal (>10kb) Multiome HiCAR | 577 | |
| chr15:76,904,474–76,906,082 | 72 bp | At TSS Multiome | 1003 | |
| chr15:76,931,243–76,932,242 | 26.3 kb | Distal (>10kb) Multiome | 693 | |
| chr15:76,973,226–76,973,843 | 68.2 kb | Distal (>10kb) Multiome | 182 | |
| chr15:77,027,800–77,028,685 | 123.0 kb | Distal (>10kb) Multiome | 156 | |
| chr15:77,070,415–77,071,533 | 165.8 kb | Distal (>10kb) Multiome | 652 |
Genomic view of the SCAPER locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.