The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CDKAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDKAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDKAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:20,271,867–20,273,198 | 261.7 kb | Distal (>10kb) Multiome HiCAR | 294 | |
| chr6:20,332,337–20,333,567 | 201.6 kb | Distal (>10kb) Multiome | 112 | |
| chr6:20,400,839–20,404,835 | 132.8 kb | Distal (>10kb) Multiome HiCAR | 1246 | |
| chr6:20,466,756–20,467,411 | 67.4 kb | Distal (>10kb) Multiome | 156 | |
| chr6:20,528,227–20,528,609 | 5.9 kb | Proximal (<10kb) | 130 | |
| chr6:20,534,312–20,534,807 | at TSS | At TSS | 739 | |
| chr6:20,538,824–20,539,149 | 4.3 kb | Proximal (<10kb) | 31 | |
| chr6:21,586,889–21,589,570 | 1054.8 kb | Distal (>10kb) Multiome HiCAR | 917 |
Genomic view of the CDKAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.