The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for PDE8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDE8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDE8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,715,472–84,717,226 | 264.2 kb | Distal (>10kb) Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 245.3 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 232.1 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 162.7 kb | Distal (>10kb) Multiome | 375 | |
| chr15:84,928,071–84,928,522 | 52.2 kb | Distal (>10kb) Multiome | 445 | |
| chr15:84,960,290–84,961,237 | 19.8 kb | Distal (>10kb) Multiome | 222 | |
| chr15:84,979,692–84,980,043 | 468 bp | At TSS | 156 | |
| chr15:84,980,278–84,982,611 | 792 bp | At TSS Multiome | 1106 | |
| chr15:84,988,061–84,988,264 | 7.5 kb | Proximal (<10kb) | 23 | |
| chr15:85,168,648–85,169,228 | 188.3 kb | Distal (>10kb) Multiome | 310 | |
| chr15:85,330,930–85,331,666 | 350.8 kb | Distal (>10kb) Multiome | 598 | |
| chr15:85,377,624–85,378,594 | 397.6 kb | Distal (>10kb) Multiome | 114 | |
| chr15:85,379,867–85,381,481 | 400.1 kb | Distal (>10kb) Multiome | 638 |
Genomic view of the PDE8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.