This module contains 11 genes including TNFRSF19, MARCHF1, STK32A, GPR173, and PRR5L, with enrichment in TNF receptor signaling and membrane protein modification pathways. Knockdown of SOX17 activates this module, while knockdown of FOXA2 and GATA6 represses it. These results suggest the module is suppressed by endoderm-specifying transcription factors during ESC-to-DE differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.