Transcription factors with Perturb-seq knockdown data for ENSG00000287092. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287092 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287092, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:155,313,962–155,315,220 | 1083.0 kb | Distal (>10kb) Multiome HiCAR | 1066 | |
| chr6:156,390,960–156,391,347 | 6.2 kb | Proximal (<10kb) | 34 | |
| chr6:156,396,765–156,397,780 | at TSS | At TSS | 180 | |
| chr6:156,400,866–156,402,632 | 3.7 kb | Proximal (<10kb) Multiome | 206 | |
| chr6:156,556,716–156,558,143 | 160.0 kb | Distal (>10kb) Multiome | 309 | |
| chr6:156,655,335–156,656,025 | 258.1 kb | Distal (>10kb) Multiome | 157 | |
| chr6:156,686,231–156,688,561 | 289.8 kb | Distal (>10kb) Multiome | 995 | |
| chr6:156,776,956–156,780,648 | 379.9 kb | Distal (>10kb) Multiome HiCAR | 985 |
Genomic view of the ENSG00000287092 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.