This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for GPR173. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR173 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR173, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:52,920,527–52,921,722 | 127.7 kb | Distal (>10kb) Multiome | 769 | |
| chrX:52,934,457–52,935,577 | 113.8 kb | Distal (>10kb) Multiome | 844 | |
| chrX:52,995,188–52,996,036 | 53.1 kb | Distal (>10kb) Multiome | 504 | |
| chrX:53,048,205–53,048,827 | 235 bp | At TSS Multiome | 184 | |
| chrX:53,081,783–53,082,862 | 33.4 kb | Distal (>10kb) Multiome | 557 | |
| chrX:53,088,446–53,088,904 | 39.9 kb | Distal (>10kb) Multiome | 204 | |
| chrX:53,093,602–53,094,629 | 45.3 kb | Distal (>10kb) Multiome | 585 | |
| chrX:53,224,805–53,225,756 | 176.6 kb | Distal (>10kb) Multiome | 825 |
Genomic view of the GPR173 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.