Transcription factors with Perturb-seq knockdown data for ENSG00000258312. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000258312 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000258312, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:97,412,529–97,413,333 | 879.5 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr12:98,291,819–98,292,796 | 373 bp | At TSS Multiome | 111 | |
| chr12:98,296,558–98,296,969 | 4.1 kb | Proximal (<10kb) | 69 | |
| chr12:98,300,464–98,300,650 | 8.0 kb | Proximal (<10kb) | 9 | |
| chr12:98,344,774–98,345,967 | 53.0 kb | Distal (>10kb) Multiome | 190 | |
| chr12:98,397,273–98,398,042 | 105.2 kb | Distal (>10kb) Multiome | 455 | |
| chr12:98,456,620–98,457,422 | 164.6 kb | Distal (>10kb) Multiome | 319 | |
| chr12:98,490,969–98,491,482 | 198.7 kb | Distal (>10kb) Multiome | 594 | |
| chr12:98,492,249–98,493,469 | 200.5 kb | Distal (>10kb) Multiome | 235 | |
| chr12:98,502,866–98,504,417 | 211.3 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:98,515,010–98,516,657 | 223.1 kb | Distal (>10kb) Multiome | 999 |
Genomic view of the ENSG00000258312 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.