Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; regulation of fibroblast migration; and regulation of primary metabolic process. Part of TORC2 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRR5L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR5L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR5L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:35,402,638–35,403,312 | 973.4 kb | Distal (>10kb) Multiome HiCAR | 55 | |
| chr11:35,617,628–35,620,590 | 758.1 kb | Distal (>10kb) Multiome HiCAR | 755 | |
| chr11:36,104,718–36,105,753 | 271.2 kb | Distal (>10kb) Multiome | 417 | |
| chr11:36,109,822–36,110,461 | 266.2 kb | Distal (>10kb) Multiome | 185 | |
| chr11:36,289,232–36,289,824 | 86.9 kb | Distal (>10kb) Multiome | 752 | |
| chr11:36,367,712–36,368,110 | 8.3 kb | Proximal (<10kb) | 41 | |
| chr11:36,371,680–36,371,893 | 4.5 kb | Proximal (<10kb) | 13 | |
| chr11:36,375,916–36,378,030 | 1.1 kb | Proximal (<10kb) Multiome | 474 | |
| chr11:36,509,026–36,510,770 | 133.9 kb | Distal (>10kb) Multiome | 984 | |
| chr11:36,594,101–36,595,067 | 218.2 kb | Distal (>10kb) Multiome | 763 |
Genomic view of the PRR5L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.