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DE-3.22

Submodule 15 genes

Structural proteins and cell motility regulation

This 15-gene module includes FGFR1, FN1, PROS1, and VCAN, with enrichment for structural molecule activity and regulation of cell motility and locomotion. Knockdown of SMAD3 activates this module. Knockdown of DR1 represses this module.

Key terms: cell motility cell migration positive regulation of neuron differentiation anatomical structure morphogenesis Notable genes: FGFR1 FN1 PROS1 VCAN FOXP2 ANK3 MGAT5 FBN2 Top TFs: SMAD3 DR1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (15)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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