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DE-3.2

Submodule 34 genes

GTPase regulation and nucleotide signaling

This 34-gene module includes NF1, MT-ND5, ANK2, ELMO1, and DOCK1, with enrichment for GTPase regulator activity and nucleoside-triphosphatase regulator activity. Knockdown of SNAI1, MYNN, and SMARCC1 activates this module. Knockdown of SOX17, FOXH1, FOXA2, SETDB1, and MARS represses this module.

Key terms: phagocytosis, engulfment plasma membrane invagination vesicle-mediated transport membrane invagination Notable genes: NF1 MT-ND5 ANK2 DOCK1 ELMO1 SNHG14 AUTS2 MT-ND6 Top TFs: SOX17 FOXH1 FOXA2 SETDB1 MARS

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (34)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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