This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ELMO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELMO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELMO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:37,247,950–37,248,849 | 200.3 kb | Distal (>10kb) Multiome | 307 | |
| chr7:37,344,876–37,345,524 | 103.6 kb | Distal (>10kb) Multiome | 174 | |
| chr7:37,357,272–37,358,173 | 91.2 kb | Distal (>10kb) Multiome HiCAR | 278 | |
| chr7:37,382,317–37,383,052 | 66.1 kb | Distal (>10kb) Multiome | 163 | |
| chr7:37,392,275–37,393,073 | 56.1 kb | Distal (>10kb) Multiome | 211 | |
| chr7:37,394,065–37,394,816 | 54.5 kb | Distal (>10kb) Multiome | 82 | |
| chr7:37,447,358–37,449,397 | 16 bp | At TSS Multiome | 636 | |
| chr7:37,491,899–37,492,627 | 43.3 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the ELMO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.