Transcription factors with Perturb-seq knockdown data for SNHG14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:24,696,121–24,697,106 | 285.5 kb | Distal (>10kb) Multiome | 21 | |
| chr15:24,763,774–24,764,745 | 217.8 kb | Distal (>10kb) Multiome | 138 | |
| chr15:24,772,852–24,773,615 | 208.8 kb | Distal (>10kb) Multiome | 402 | |
| chr15:24,955,779–24,956,897 | 25.5 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the SNHG14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.