DE-3

DE-3.19

Submodule 17 genes

Hepatic differentiation and cell migration regulators

This module contains 17 genes including DPP4, HNF1B, MTSS1, PITX1, and RGS5, with enrichment in hepatic differentiation, cell migration, and cytoskeletal organization. Knockdown of CTBP1 activates this module. No repressing transcription factors were identified.

Notable genes: DPP4 HNF1B MTSS1 PITX1 RGS5 MTA3 SRGAP1 PPIP5K2 Top TFs: CTBP1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (15)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z