RGS5

regulator of G protein signaling 5

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

Member of: DE-3 DE-3.19 Developmental clusters: GC5

Biological processes 14 terms

G protein-coupled receptor signaling pathway (GO:0007186)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activity (GO:0003924)GTPase activity (GO:0003924)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)membrane (GO:0016020)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)negative regulation of vascular associated smooth muscle cell proliferation (GO:1904706)plasma membrane (GO:0005886)protein binding (GO:0005515)regulation of G protein-coupled receptor signaling pathway (GO:0008277)

Expression (TPM)

TFs regulating RGS5 0 TFs

Transcription factors with Perturb-seq knockdown data for RGS5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RGS5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:163,069,170–163,069,674	252.4 kb	Distal (>10kb) Multiome HiCAR	172
chr1:163,195,927–163,196,435	125.6 kb	Distal (>10kb) Multiome	275
chr1:163,196,575–163,196,702	6.2 kb	Proximal (<10kb)	27
chr1:163,202,883–163,203,536	118.6 kb	Distal (>10kb) Multiome	178
chr1:163,203,664–163,203,966	748 bp	At TSS	20
chr1:163,312,429–163,312,953	8.8 kb	Proximal (<10kb)	17
chr1:163,321,363–163,322,459	167 bp	At TSS Multiome	1184
chr1:163,399,976–163,400,589	78.5 kb	Distal (>10kb) Multiome	146
chr1:163,561,453–163,562,798	240.3 kb	Distal (>10kb) Multiome	254
chr1:163,590,875–163,591,911	269.7 kb	Distal (>10kb) Multiome	191
chr1:163,595,781–163,597,181	274.6 kb	Distal (>10kb) Multiome	255
chr1:164,774,689–164,775,602	1453.4 kb	Distal (>10kb) Multiome HiCAR	367

Genome Browser

Genomic view of the RGS5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.