Enables actin monomer binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including adherens junction maintenance; positive regulation of actin filament bundle assembly; and renal tubule development. Predicted to act upstream of or within several processes, including actin filament polymerization; bone mineralization; and magnesium ion homeostasis. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MTSS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTSS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTSS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:124,473,813–124,475,636 | 253.7 kb | Distal (>10kb) Multiome | 970 | |
| chr8:124,538,847–124,539,474 | 189.4 kb | Distal (>10kb) Multiome | 921 | |
| chr8:124,635,289–124,635,776 | 92.9 kb | Distal (>10kb) Multiome | 230 | |
| chr8:124,720,207–124,720,745 | 7.7 kb | Proximal (<10kb) | 274 | |
| chr8:124,726,992–124,728,984 | 91 bp | At TSS Multiome | 609 | |
| chr8:124,830,627–124,831,574 | 102.6 kb | Distal (>10kb) Multiome | 135 | |
| chr8:124,908,848–124,909,459 | 180.7 kb | Distal (>10kb) Multiome | 23 | |
| chr8:124,963,890–124,964,452 | 235.6 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chr8:124,973,135–124,973,609 | 244.9 kb | Distal (>10kb) Multiome | 684 | |
| chr8:124,997,595–124,999,115 | 269.9 kb | Distal (>10kb) Multiome | 836 |
Genomic view of the MTSS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.