The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for SRGAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRGAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRGAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:63,667,866–63,669,610 | 175.1 kb | Distal (>10kb) Multiome | 357 | |
| chr12:63,779,430–63,780,603 | 63.8 kb | Distal (>10kb) Multiome | 817 | |
| chr12:63,839,279–63,839,851 | 3.9 kb | Proximal (<10kb) | 121 | |
| chr12:63,843,303–63,845,210 | 124 bp | At TSS Multiome | 940 | |
| chr12:64,005,965–64,006,741 | 162.6 kb | Distal (>10kb) Multiome | 140 | |
| chr12:64,221,528–64,222,890 | 378.5 kb | Distal (>10kb) Multiome HiCAR | 970 | |
| chr12:64,390,059–64,390,977 | 546.9 kb | Distal (>10kb) Multiome HiCAR | 268 | |
| chr12:64,403,794–64,405,423 | 560.6 kb | Distal (>10kb) Multiome HiCAR | 1007 |
Genomic view of the SRGAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.