This module comprises 38 genes including ABL1, ADAM10, WRN, and XPO1, with top enrichment in DNA repair, nucleotide metabolism, and protein transport. Knockdown of SOX17 activates this module, while knockdown of EOMES and GATA4 represses it. These patterns suggest coordinated suppression of DNA maintenance pathways during early endoderm specification.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.