This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for PKD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PKD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PKD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:87,921,767–87,922,408 | 85.6 kb | Distal (>10kb) Multiome | 58 | |
| chr4:88,006,620–88,008,542 | 15 bp | At TSS Multiome | 543 | |
| chr4:88,112,943–88,113,755 | 105.8 kb | Distal (>10kb) Multiome | 47 | |
| chr4:88,158,357–88,159,406 | 151.3 kb | Distal (>10kb) Multiome | 719 | |
| chr4:88,178,032–88,179,178 | 170.9 kb | Distal (>10kb) Multiome | 219 | |
| chr4:88,283,347–88,285,223 | 277.1 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the PKD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.