Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for ADAM10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAM10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAM10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:58,252,606–58,253,772 | 496.6 kb | Distal (>10kb) Multiome HiCAR | 116 | |
| chr15:58,561,174–58,561,683 | 188.3 kb | Distal (>10kb) Multiome | 27 | |
| chr15:58,748,777–58,750,495 | 115 bp | At TSS Multiome | 819 | |
| chr15:58,770,593–58,772,279 | 21.4 kb | Distal (>10kb) Multiome | 996 | |
| chr15:58,833,690–58,834,207 | 84.2 kb | Distal (>10kb) Multiome | 126 | |
| chr15:58,864,709–58,865,675 | 115.3 kb | Distal (>10kb) Multiome | 533 | |
| chr15:58,932,998–58,934,288 | 183.9 kb | Distal (>10kb) Multiome | 943 | |
| chr15:58,987,470–58,988,521 | 238.1 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the ADAM10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.