The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for LIN28B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LIN28B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LIN28B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:104,859,146–104,860,267 | 97.3 kb | Distal (>10kb) Multiome | 883 | |
| chr6:104,940,109–104,942,073 | 15.5 kb | Distal (>10kb) Multiome | 831 | |
| chr6:104,952,936–104,954,114 | 3.4 kb | Proximal (<10kb) Multiome | 355 | |
| chr6:104,955,587–104,956,441 | 1.1 kb | Proximal (<10kb) Multiome | 520 | |
| chr6:104,956,943–104,957,947 | 323 bp | At TSS Multiome | 491 | |
| chr6:104,958,059–104,958,190 | 953 bp | At TSS | 89 | |
| chr6:105,136,176–105,137,720 | 180.0 kb | Distal (>10kb) Multiome | 532 | |
| chr6:105,179,230–105,180,501 | 222.7 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the LIN28B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.