This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Transcription factors with Perturb-seq knockdown data for ABL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:130,433,040–130,433,900 | 279.6 kb | Distal (>10kb) Multiome | 543 | |
| chr9:130,444,394–130,446,012 | 268.2 kb | Distal (>10kb) Multiome | 568 | |
| chr9:130,446,125–130,446,731 | 266.6 kb | Distal (>10kb) Multiome | 326 | |
| chr9:130,578,979–130,579,997 | 133.5 kb | Distal (>10kb) Multiome | 855 | |
| chr9:130,663,509–130,664,148 | 49.0 kb | Distal (>10kb) Multiome | 159 | |
| chr9:130,681,081–130,682,308 | 31.5 kb | Distal (>10kb) Multiome | 836 | |
| chr9:130,689,990–130,690,532 | 22.8 kb | Distal (>10kb) Multiome | 331 | |
| chr9:130,692,215–130,692,841 | 20.6 kb | Distal (>10kb) Multiome | 141 | |
| chr9:130,693,327–130,694,076 | 19.3 kb | Distal (>10kb) Multiome | 752 | |
| chr9:130,712,289–130,713,655 | 266 bp | At TSS Multiome | 791 | |
| chr9:130,834,623–130,835,640 | 122.2 kb | Distal (>10kb) Multiome HiCAR | 715 | |
| chr9:130,940,926–130,941,385 | 228.2 kb | Distal (>10kb) Multiome | 359 | |
| chr9:130,998,218–130,998,819 | 285.4 kb | Distal (>10kb) Multiome HiCAR | 380 | |
| chr9:131,008,758–131,009,603 | 296.1 kb | Distal (>10kb) Multiome HiCAR | 393 |
Genomic view of the ABL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.