This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for WRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:30,743,665–30,744,537 | 289.6 kb | Distal (>10kb) Multiome | 789 | |
| chr8:30,811,955–30,813,256 | 221.0 kb | Distal (>10kb) Multiome | 824 | |
| chr8:30,817,124–30,817,779 | 216.3 kb | Distal (>10kb) Multiome | 166 | |
| chr8:30,911,618–30,912,683 | 121.6 kb | Distal (>10kb) Multiome | 460 | |
| chr8:31,032,234–31,034,302 | 95 bp | At TSS Multiome | 723 | |
| chr8:31,034,565–31,034,905 | 778 bp | At TSS | 263 | |
| chr8:31,238,723–31,239,626 | 205.3 kb | Distal (>10kb) Multiome | 327 |
Genomic view of the WRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.