This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TP53BP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53BP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53BP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:223,711,902–223,713,324 | 133.3 kb | Distal (>10kb) Multiome | 708 | |
| chr1:223,748,526–223,749,571 | 96.8 kb | Distal (>10kb) Multiome | 391 | |
| chr1:223,839,235–223,839,449 | 6.3 kb | Proximal (<10kb) | 37 | |
| chr1:223,845,336–223,846,577 | 266 bp | At TSS Multiome | 1001 | |
| chr1:223,870,523–223,871,422 | 25.1 kb | Distal (>10kb) Multiome | 131 | |
| chr1:223,992,339–223,993,214 | 146.9 kb | Distal (>10kb) Multiome | 350 | |
| chr1:224,113,911–224,114,795 | 268.3 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the TP53BP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.