Enables fibroblast growth factor receptor binding activity and neurotrophin TRKA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FRS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FRS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FRS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:69,170,145–69,170,803 | 299.9 kb | Distal (>10kb) Multiome | 33 | |
| chr12:69,171,748–69,172,291 | 298.3 kb | Distal (>10kb) Multiome | 92 | |
| chr12:69,238,925–69,240,549 | 230.9 kb | Distal (>10kb) Multiome | 828 | |
| chr12:69,330,668–69,333,363 | 137.6 kb | Distal (>10kb) Multiome | 710 | |
| chr12:69,359,411–69,360,582 | 110.4 kb | Distal (>10kb) Multiome | 990 | |
| chr12:69,468,282–69,468,627 | 1.8 kb | Proximal (<10kb) | 88 | |
| chr12:69,470,012–69,471,069 | 12 bp | At TSS Multiome | 831 | |
| chr12:69,585,221–69,586,062 | 115.2 kb | Distal (>10kb) Multiome | 1005 | |
| chr12:69,738,320–69,740,119 | 268.4 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the FRS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.