This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]
Transcription factors with Perturb-seq knockdown data for ADCY6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADCY6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADCY6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:48,681,532–48,682,844 | 106.8 kb | Distal (>10kb) Multiome | 933 | |
| chr12:48,716,299–48,717,435 | 72.2 kb | Distal (>10kb) Multiome | 1077 | |
| chr12:48,788,600–48,789,901 | 231 bp | At TSS Multiome | 478 | |
| chr12:48,795,703–48,796,330 | 6.9 kb | Proximal (<10kb) Multiome | 333 | |
| chr12:48,814,087–48,815,981 | 25.7 kb | Distal (>10kb) Multiome | 815 | |
| chr12:48,817,927–48,819,273 | 29.5 kb | Distal (>10kb) Multiome | 459 | |
| chr12:48,851,862–48,852,825 | 63.1 kb | Distal (>10kb) Multiome | 900 | |
| chr12:48,864,974–48,866,292 | 76.8 kb | Distal (>10kb) Multiome | 649 | |
| chr12:48,883,231–48,884,168 | 94.7 kb | Distal (>10kb) Multiome | 433 | |
| chr12:48,890,671–48,891,380 | 101.9 kb | Distal (>10kb) Multiome | 517 | |
| chr12:48,924,659–48,925,688 | 135.8 kb | Distal (>10kb) Multiome | 413 | |
| chr12:48,956,252–48,957,974 | 167.4 kb | Distal (>10kb) Multiome | 831 | |
| chr12:48,978,055–48,978,819 | 189.2 kb | Distal (>10kb) Multiome | 360 | |
| chr12:48,980,647–48,981,153 | 191.8 kb | Distal (>10kb) Multiome | 259 | |
| chr12:48,997,612–48,998,829 | 209.2 kb | Distal (>10kb) Multiome | 620 | |
| chr12:49,018,007–49,019,184 | 229.6 kb | Distal (>10kb) Multiome | 899 | |
| chr12:49,059,883–49,061,347 | 271.7 kb | Distal (>10kb) Multiome | 1060 | |
| chr12:49,069,381–49,070,589 | 280.9 kb | Distal (>10kb) Multiome | 804 | |
| chr12:49,088,153–49,088,744 | 299.4 kb | Distal (>10kb) Multiome | 473 |
Genomic view of the ADCY6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.