This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for GAN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:81,035,394–81,036,490 | 279.1 kb | Distal (>10kb) Multiome | 711 | |
| chr16:81,076,439–81,077,802 | 237.9 kb | Distal (>10kb) Multiome | 982 | |
| chr16:81,083,340–81,084,144 | 231.2 kb | Distal (>10kb) Multiome | 13 | |
| chr16:81,095,766–81,096,892 | 218.5 kb | Distal (>10kb) Multiome | 856 | |
| chr16:81,180,983–81,181,563 | 133.6 kb | Distal (>10kb) Multiome | 479 | |
| chr16:81,314,548–81,315,884 | 33 bp | At TSS Multiome | 933 | |
| chr16:81,403,561–81,404,209 | 88.8 kb | Distal (>10kb) Multiome | 694 | |
| chr16:81,443,946–81,445,799 | 129.7 kb | Distal (>10kb) Multiome | 618 | |
| chr16:81,558,602–81,559,161 | 244.0 kb | Distal (>10kb) Multiome | 376 |
Genomic view of the GAN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.