MAP3K21

mitogen-activated protein kinase kinase kinase 21 | KIAA1804, MLK4

Predicted to enable JUN kinase kinase kinase activity and protein homodimerization activity. Predicted to be involved in protein autophosphorylation and signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.28 Developmental clusters: GC4

Biological processes 12 terms

ATP binding (GO:0005524)JUN kinase kinase kinase activity (GO:0004706)MAP kinase kinase kinase activity (GO:0004709)MAPK cascade (GO:0000165)cytoplasm (GO:0005737)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating MAP3K21 0 TFs

Transcription factors with Perturb-seq knockdown data for MAP3K21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAP3K21

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:233,228,052–233,228,602	99.4 kb	Distal (>10kb) Multiome	34
chr1:233,233,376–233,234,177	93.9 kb	Distal (>10kb) Multiome	143
chr1:233,289,493–233,290,196	37.9 kb	Distal (>10kb) Multiome	155
chr1:233,294,969–233,295,863	32.1 kb	Distal (>10kb) Multiome	466
chr1:233,326,831–233,329,042	192 bp	At TSS Multiome	601
chr1:233,471,138–233,474,579	144.1 kb	Distal (>10kb) Multiome	432
chr1:233,587,899–233,588,712	260.6 kb	Distal (>10kb) Multiome	287
chr1:233,613,392–233,615,436	286.2 kb	Distal (>10kb) Multiome	660
chr1:234,075,263–234,075,988	748.1 kb	Distal (>10kb) Multiome HiCAR	61
chr1:234,092,919–234,093,755	765.6 kb	Distal (>10kb) Multiome HiCAR	62
chr1:234,214,031–234,215,631	887.5 kb	Distal (>10kb) Multiome HiCAR	327
chr1:234,229,899–234,231,030	902.8 kb	Distal (>10kb) Multiome HiCAR	183
chr1:234,372,993–234,374,088	1045.8 kb	Distal (>10kb) Multiome HiCAR	1034
chr1:234,490,875–234,491,564	1163.4 kb	Distal (>10kb) Multiome HiCAR	380
chr1:235,093,150–235,094,131	1766.0 kb	Distal (>10kb) Multiome HiCAR	491

Genome Browser

Genomic view of the MAP3K21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.