PAFAH1B2

platelet activating factor acetylhydrolase 1b catalytic subunit 2

Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

Member of: DE-2 DE-2.25

Biological processes 28 terms

1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847)1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847)1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847)1-alkyl-2-acetylglycerophosphocholine esterase complex (GO:0008247)1-alkyl-2-acetylglycerophosphocholine esterase complex (GO:0008247)1-alkyl-2-acetylglycerophosphocholine esterase complex (GO:0008247)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)identical protein binding (GO:0042802)lipid metabolic process (GO:0006629)platelet activating factor catabolic process (GO:0062234)platelet-activating factor acetyltransferase activity (GO:0047179)platelet-activating factor acetyltransferase activity (GO:0047179)positive regulation of macroautophagy (GO:0016239)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein-containing complex binding (GO:0044877)secretory granule lumen (GO:0034774)spermatogenesis (GO:0007283)spermatogenesis (GO:0007283)

Expression (TPM)

TFs regulating PAFAH1B2 0 TFs

Transcription factors with Perturb-seq knockdown data for PAFAH1B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAFAH1B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PAFAH1B2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAFAH1B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:116,732,600–116,733,018	411.5 kb	Distal (>10kb) Multiome HiCAR	240
chr11:116,791,118–116,791,887	352.9 kb	Distal (>10kb) Multiome HiCAR	473
chr11:116,835,609–116,836,611	308.3 kb	Distal (>10kb) Multiome HiCAR	666
chr11:117,097,570–117,099,243	45.9 kb	Distal (>10kb) Multiome	739
chr11:117,099,458–117,100,103	44.4 kb	Distal (>10kb) Multiome	62
chr11:117,138,729–117,138,924	5.4 kb	Proximal (<10kb)	97
chr11:117,143,916–117,144,864	11 bp	At TSS Multiome	969
chr11:117,178,198–117,179,718	34.5 kb	Distal (>10kb) Multiome	726
chr11:117,197,957–117,198,434	53.7 kb	Distal (>10kb) Multiome	160
chr11:117,198,962–117,199,797	55.0 kb	Distal (>10kb) Multiome	211
chr11:117,231,703–117,233,431	88.2 kb	Distal (>10kb) Multiome	703
chr11:117,315,726–117,316,638	172.0 kb	Distal (>10kb) Multiome	619
chr11:117,327,486–117,328,627	183.6 kb	Distal (>10kb) Multiome	751
chr11:117,410,817–117,412,004	267.0 kb	Distal (>10kb) Multiome	247
chr11:117,429,727–117,430,361	285.8 kb	Distal (>10kb) Multiome	126
chr11:117,443,412–117,443,876	299.4 kb	Distal (>10kb) Multiome	185

Genome Browser

Genomic view of the PAFAH1B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.