This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for NCOA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCOA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCOA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:45,791,633–45,792,259 | 298.0 kb | Distal (>10kb) Multiome | 882 | |
| chr20:45,812,087–45,813,052 | 277.5 kb | Distal (>10kb) Multiome | 695 | |
| chr20:45,833,493–45,834,622 | 256.0 kb | Distal (>10kb) Multiome | 833 | |
| chr20:45,856,871–45,858,137 | 232.4 kb | Distal (>10kb) Multiome | 884 | |
| chr20:45,880,796–45,881,524 | 208.8 kb | Distal (>10kb) Multiome | 738 | |
| chr20:45,890,127–45,891,800 | 198.6 kb | Distal (>10kb) Multiome | 1095 | |
| chr20:45,910,538–45,912,397 | 177.7 kb | Distal (>10kb) Multiome | 713 | |
| chr20:45,933,591–45,935,780 | 154.8 kb | Distal (>10kb) Multiome | 1195 | |
| chr20:45,971,553–45,972,790 | 117.8 kb | Distal (>10kb) Multiome | 1206 | |
| chr20:46,004,647–46,005,315 | 85.0 kb | Distal (>10kb) Multiome | 207 | |
| chr20:46,011,604–46,012,166 | 78.0 kb | Distal (>10kb) Multiome | 239 | |
| chr20:46,013,565–46,014,586 | 75.8 kb | Distal (>10kb) Multiome | 735 | |
| chr20:46,021,209–46,023,166 | 68.0 kb | Distal (>10kb) Multiome | 679 | |
| chr20:46,031,750–46,032,261 | 57.9 kb | Distal (>10kb) Multiome | 227 | |
| chr20:46,058,408–46,058,983 | 31.2 kb | Distal (>10kb) Multiome | 123 | |
| chr20:46,089,092–46,090,355 | 70 bp | At TSS Multiome | 1047 | |
| chr20:46,091,736–46,092,300 | 2.3 kb | Proximal (<10kb) Multiome | 38 | |
| chr20:46,117,897–46,118,755 | 28.3 kb | Distal (>10kb) Multiome | 376 | |
| chr20:46,174,457–46,175,011 | 84.8 kb | Distal (>10kb) Multiome | 277 | |
| chr20:46,268,041–46,268,560 | 178.4 kb | Distal (>10kb) Multiome | 82 | |
| chr20:46,307,134–46,307,979 | 217.3 kb | Distal (>10kb) Multiome | 455 | |
| chr20:46,308,245–46,308,857 | 218.7 kb | Distal (>10kb) Multiome | 287 | |
| chr20:46,363,898–46,364,657 | 274.4 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the NCOA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.