Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in exon-exon junction complex and nuclear speck. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PNN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PNN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PNN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:39,102,463–39,103,834 | 72.0 kb | Distal (>10kb) Multiome | 1067 | |
| chr14:39,114,070–39,114,631 | 60.9 kb | Distal (>10kb) Multiome | 834 | |
| chr14:39,169,826–39,170,847 | 4.8 kb | Proximal (<10kb) Multiome | 1008 | |
| chr14:39,174,486–39,175,885 | 147 bp | At TSS Multiome | 1141 | |
| chr14:39,181,460–39,181,952 | 6.2 kb | Proximal (<10kb) | 107 | |
| chr14:39,187,192–39,188,875 | 8.1 kb | Proximal (<10kb) | 200 | |
| chr14:39,203,536–39,204,758 | 28.9 kb | Distal (>10kb) Multiome | 293 | |
| chr14:39,266,213–39,267,903 | 91.9 kb | Distal (>10kb) Multiome | 1124 | |
| chr14:39,431,232–39,433,633 | 257.4 kb | Distal (>10kb) Multiome | 1121 |
Genomic view of the PNN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.