This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for SSX2IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSX2IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSX2IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:84,479,129–84,479,871 | 211.0 kb | Distal (>10kb) Multiome | 843 | |
| chr1:84,505,605–84,506,945 | 184.1 kb | Distal (>10kb) Multiome | 937 | |
| chr1:84,573,555–84,574,858 | 116.2 kb | Distal (>10kb) Multiome | 896 | |
| chr1:84,582,867–84,584,410 | 107.1 kb | Distal (>10kb) Multiome | 288 | |
| chr1:84,602,350–84,604,845 | 87.1 kb | Distal (>10kb) Multiome | 490 | |
| chr1:84,611,743–84,612,319 | 78.4 kb | Distal (>10kb) Multiome | 53 | |
| chr1:84,620,449–84,621,260 | 69.5 kb | Distal (>10kb) Multiome | 711 | |
| chr1:84,685,390–84,685,564 | 4.7 kb | Proximal (<10kb) | 17 | |
| chr1:84,686,311–84,686,759 | 3.5 kb | Proximal (<10kb) | 29 | |
| chr1:84,688,813–84,689,128 | 1.2 kb | Proximal (<10kb) | 227 | |
| chr1:84,689,238–84,689,497 | 806 bp | At TSS | 51 | |
| chr1:84,689,823–84,691,321 | 88 bp | At TSS Multiome | 784 | |
| chr1:84,691,484–84,691,791 | 1.2 kb | Proximal (<10kb) | 66 | |
| chr1:84,892,367–84,893,746 | 202.7 kb | Distal (>10kb) Multiome | 406 | |
| chr1:84,944,592–84,945,445 | 254.5 kb | Distal (>10kb) Multiome | 438 |
Genomic view of the SSX2IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.